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lorlatinib MeSH Supplementary Concept Data 2021


MeSH Supplementary
lorlatinib
Unique ID
C000590786
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C000590786
Entry Term(s)
(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile
7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile
Lorbrena
PF-06463922
PF06463922
loratinib
Registry Number
OSP71S83EU
Heading Mapped to
*Aminopyridines
*Lactams
*Pyrazoles
Frequency
131
Note
inhibits both anaplastic lymphoma kinase and c-ros oncogene 1 (ROS1) protein
Source
J Med Chem. 2014 Jun 12;57(11):4720-44.
Date of Entry
2014/08/17
Revision Date
2021/09/09
lorlatinib Preferred
PF-06463922 Narrower
Lorbrena Narrower
7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile Broader
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