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trichostatin A MeSH Supplementary Concept Data 2023


MeSH Supplementary
trichostatin A
Unique ID
C012589
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C012589
Entry Term(s)
2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-
7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
A 300
TSA antibioitc
Pharm Action
Antifungal Agents
Protein Synthesis Inhibitors
Histone Deacetylase Inhibitors
Registry Number
3X2S926L3Z
Related Numbers
58880-19-6
Previous Indexing
HYDROXAMIC ACIDS (76-94)
Heading Mapped to
*Hydroxamic Acids
Frequency
3173
Note
chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES
Source
J Antibiot (Tokyo) 29(1):1;1976
J Antibiot (Tokyo) 31(10):939;1978
Date of Entry
1976/01/01
Revision Date
2020/08/19
trichostatin A Preferred
A 300 Narrower
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