MeSH Browser

MeSH Supplementary: pretomanid
Unique ID: C410767
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C410767
Entry Term(s): 2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine; PA 824; PA-824; PA824 cpd
Registry Number: 0
Heading Mapped to: *Nitroimidazoles
Frequency: 174
Note: nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source
Source: Nature. 2000 Jun 22;405(6789):962-6
Indexing Information: Antitubercular Agents
Date of Entry: 2000/07/18
Revision Date: 2019/08/28

pretomanid MeSH Supplementary Concept Data 2023