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pretomanid MeSH Supplementary Concept Data 2023


MeSH Supplementary
pretomanid
Unique ID
C410767
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C410767
Entry Term(s)
2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
PA 824
PA-824
PA824 cpd
Registry Number
0
Heading Mapped to
*Nitroimidazoles
Frequency
166
Note
nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source
Source
Nature. 2000 Jun 22;405(6789):962-6
Indexing Information
Antitubercular Agents
Date of Entry
2000/07/18
Revision Date
2019/08/28
pretomanid Preferred
PA 824 Narrower
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