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N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide MeSH Supplementary Concept Data 2023


MeSH Supplementary
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Unique ID
C484278
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C484278
Entry Term(s)
LY 411,575
LY 411575
LY 450139
LY-411,575
LY-411575
LY411,575
LY411575
LY450139
N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide
Semagacestat
Pharm Action
Gamma Secretase Inhibitors and Modulators
Registry Number
0
Heading Mapped to
Alanine / *analogs & derivatives
*Azepines
Frequency
102
Note
a gamma-secretase inhibitor
Source
J Pharmacol Exp Ther. 2004 Apr;309(1):49-55
Date of Entry
2004/04/28
Revision Date
2021/08/09
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide Preferred
Semagacestat Narrower
N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide Broader
LY 411575 Narrower
LY 450139 Related
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