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aplaviroc MeSH Supplementary Concept Data 2023


MeSH Supplementary
aplaviroc
Unique ID
C499671
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C499671
Entry Term(s)
4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride
GW873140
benzoic acid, 4-(4-(((3R)-1-butyl-3-((R)-cyclohexylhydroxymethyl)-2,5-dioxo-1,4,9- triazaspiro(55)undec-9-yl)methyl)phenoxy)-
rac-4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid
Pharm Action
HIV Fusion Inhibitors
Registry Number
98B425P30V
Heading Mapped to
*Benzoates
*Piperazines
*Spiro Compounds
*Diketopiperazines
Frequency
30
Note
a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source
Source
Mol Pharmacol 2005 Apr;67(4):1268-82
Date of Entry
2005/04/18
Revision Date
2020/11/24
aplaviroc Preferred
rac-4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid Broader
GW873140 Narrower
4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride Broader
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