Maxillofacial abnormalities characterized by a short nose with a flat bridge, a short columella, an acute nasolabial angle, perialar flatness, a convex upper lip, and a tendency to an ANGLE CLASS III MALOCCLUSION. Critical features of the syndrome appear to be midfacial hypoplasia, lack of anterior nasal spine, and malocclusion. May be hereditary (autosomal recessive) or multifactorial. OMIM: 155050