MeSH Browser

MeSH Heading: Wolframin
Tree Number(s): D12.776.543.304
Unique ID: D000099396
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099396
Scope Note: A transmembrane protein located primarily in the ENDOPLASMIC RETICULUM (ER) that functions to regulate the storage of CALCIUM in the ER as well as ENDOPLASMIC RETICULUM STRESS. Mutations in the gene that encodes wolframin cause WOLFRAM SYNDROME.
Entry Term(s): WFS1 Protein; Wolframin Protein; Wolframin Syndrome Protein 1
Registry Numbers: 0
Public MeSH Note: 2027; see WOLFRAMIN PROTEIN (NM) 1998-2026; WOLFRAMIN was indexed under MEMBRANE PROTEINS 1998-2026
History Note: 2027 (1998); use WOLFRAMIN PROTEIN (NM) 1998-2026
Date Introduced: 2027/01/01
Last Updated: 2027/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000769551
Registry Numbers: 0
Scope Note: A transmembrane protein located primarily in the ENDOPLASMIC RETICULUM (ER) that functions to regulate the storage of CALCIUM in the ER as well as ENDOPLASMIC RETICULUM STRESS. Mutations in the gene that encodes wolframin cause WOLFRAM SYNDROME.
Terms: Wolframin Preferred Term
Term UI T001150602
Date01/13/2026
LexicalTag NON
ThesaurusID NLM (2027); Wolframin Protein
Term UI T001150607
Date01/13/2026
LexicalTag NON
ThesaurusID NLM (1998); WFS1 Protein
Term UI T001152393
Date04/07/2026
LexicalTag ABX
ThesaurusID NLM (2027); Wolframin Syndrome Protein 1
Term UI T001152394
Date04/07/2026
LexicalTag NON
ThesaurusID NLM (2027)

Wolframin MeSH Descriptor Data 2027