MeSH Browser

MeSH Heading: Olivopontocerebellar Atrophies
Tree Number(s): C10.177.575.550.375; C10.228.140.079.612.600; C10.228.140.252.700.650; C10.228.662.550.600; C10.228.854.787.750; C10.574.500.825.650; C16.320.400.780.750
Unique ID: D009849
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009849
Scope Note: A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)
Entry Version: OPCA
Entry Term(s): Dejerine-Thomas Syndrome; Familial Olivopontocerebellar Atrophy; Inherited Olivopontocerebellar Atrophy; Nonfamilial Olivopontocerebellar Atrophy; Olivo-Ponto-Cerebellar Atrophy; Olivo-Ponto-Cerebellar Degeneration; Olivopontocerebellar Atrophy; Olivopontocerebellar Atrophy, Idiopathic; Olivopontocerebellar Degeneration; Olivopontocerebellar Hypoplasia; Pontoolivocerebellar Atrophy; Presenile Ataxia
Previous Indexing: Atrophy (1966-1986); Brain Diseases (1966-1986); Cerebellar Ataxia (1968-1986); Cerebellar Diseases (1966-1986); Olivary Nucleus (1966-1986); Pons (1966-1986)
See Also: Olivary Degeneration
Public MeSH Note: 2000; see OLIVOPONTOCEREBELLAR ATROPHY 1991-1999, see SPINOCEREBELLAR DEGENERATION 1987-1990
History Note: 2000(1987)
Date Established: 1991/01/01
Date of Entry: 1986/03/31
Revision Date: 2023/02/26

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Autonomic Nervous System Diseases [C10.177]
  - Primary Dysautonomias [C10.177.575]
    - Multiple System Atrophy [C10.177.575.550]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Basal Ganglia Diseases [C10.228.140.079]
      - Multiple System Atrophy [C10.228.140.079.612]
        
        Olivopontocerebellar Atrophies [C10.228.140.079.612.600]
        
        Shy-Drager Syndrome [C10.228.140.079.612.700]
        
        Striatonigral Degeneration [C10.228.140.079.612.800]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Cerebellar Diseases [C10.228.140.252]
      - Spinocerebellar Degenerations [C10.228.140.252.700]
        
        Friedreich Ataxia [C10.228.140.252.700.150]
        
        Myoclonic Cerebellar Dyssynergia [C10.228.140.252.700.250]
        
        Olivopontocerebellar Atrophies [C10.228.140.252.700.650]
        
        Spinocerebellar Ataxias [C10.228.140.252.700.700]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Movement Disorders [C10.228.662]
    - Multiple System Atrophy [C10.228.662.550]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Spinal Cord Diseases [C10.228.854]
    - Spinocerebellar Degenerations [C10.228.854.787]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]
    - Spinocerebellar Degenerations [C10.574.500.825]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Spinocerebellar Degenerations [C16.320.400.780]

Olivopontocerebellar Atrophies Preferred

Olivopontocerebellar Atrophy, Idiopathic Narrower

Familial Olivopontocerebellar Atrophy Narrower

Nonfamilial Olivopontocerebellar Atrophy Narrower

Olivopontocerebellar Hypoplasia Related

Olivopontocerebellar Atrophies MeSH Descriptor Data 2025