NLM Logo

Perilipins MeSH Descriptor Data 2023


MeSH Heading
Perilipins
Tree Number(s)
D12.776.157.464.500
Unique ID
D000070137
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000070137
Scope Note
A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
Entry Term(s)
PAT Proteins
PLIN Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
Registry Number
0
Previous Indexing
Carrier Proteins (1991-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/01/19
Perilipins Preferred
page delivered in 0.146s