MeSH Browser

MeSH Heading: Nogo Proteins
Tree Number(s): D12.776.543.620.738; D12.776.631.580.738
Unique ID: D000070798
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000070798
Scope Note: Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Entry Term(s): NI-220 Protein; NI-250 Protein; NI-35 Protein; NI-35-250; Neurite Growth Inhibitor 35-350; Nogo Protein; Nogo-66 Protein; Nogo-A Protein; Nogo-B Protein; Nogo-C Protein; Reticulon 4-B Protein; Reticulon-4 Protein
Public MeSH Note: 2017; NOGO PROTEIN was indexed under MYELIN PROTEINS 2000-2016
History Note: 2017 (2000)
Date Established: 2017/01/01
Date of Entry: 2016/07/11
Revision Date: 2016/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0356759
Scope Note: Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Terms: Nogo Proteins Preferred Term
Term UI T000891836
Date12/09/2015
LexicalTag NON
ThesaurusID NLM (2017); Nogo Protein
Term UI T000891307
Date11/30/2015
LexicalTag NON
ThesaurusID NLM (2000); Reticulon-4 Protein
Term UI T000891308
Date11/30/2015
LexicalTag NON
ThesaurusID NLM (2007)

Nogo Proteins MeSH Descriptor Data 2025