MeSH Browser

MeSH Heading: Solute Carrier Family 22 Member 5
Tree Number(s): D12.776.157.530.450.250.812.750; D12.776.157.530.937.612.750; D12.776.543.585.450.250.812.750; D12.776.543.585.937.701.750
Unique ID: D000074058
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074058
Scope Note: A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.
Entry Term(s): High-Affinity Carnitine Transporter; OCTN2 Protein; Organic Cation-Carnitine Transporter 2; SLC22A5 Protein; Sodium-Dependent Carnitine Cotransporter
Registry Numbers: 0
Previous Indexing: Carrier Proteins (1998-2017); Organic Cation Transport Proteins (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/03/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625386
Registry Numbers: 0
Scope Note: A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.
Terms: Solute Carrier Family 22 Member 5 Preferred Term
Term UI T000913880
Date01/09/2017
LexicalTag NON
ThesaurusID NLM (2018); Organic Cation-Carnitine Transporter 2
Term UI T000913876
Date01/09/2017
LexicalTag NON
ThesaurusID NLM (2018); SLC22A5 Protein
Term UI T000913878
Date01/09/2017
LexicalTag ABX
ThesaurusID NLM (2018); OCTN2 Protein
Term UI T000913879
Date01/09/2017
LexicalTag ABX
ThesaurusID NLM (2018); Sodium-Dependent Carnitine Cotransporter
Term UI T000913881
Date01/09/2017
LexicalTag NON
ThesaurusID NLM (2018); High-Affinity Carnitine Transporter
Term UI T000913882
Date01/09/2017
LexicalTag NON
ThesaurusID NLM (2018)

Solute Carrier Family 22 Member 5 MeSH Descriptor Data 2024