MeSH Browser

MeSH Heading: Angiopoietin-Like Protein 4
Tree Number(s): D12.644.276.100.050.400; D12.776.467.100.050.400; D23.529.100.050.400
Unique ID: D000075803
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075803
Scope Note: A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.
Entry Term(s): ANGPTL4 Protein; Angiopoietin-related Protein 4
Registry Number: 0
Previous Indexing: Angiopoietins (2004-2017); Blood Proteins (2000-2017)
Public MeSH Note: 2022: see ANGIOPOIETIN-LIKE 4 PROTEIN 2018-2021
History Note: 2022(2018)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/06/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000631469
Registry Number: 0
Scope Note: A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.
Terms: Angiopoietin-Like Protein 4 Preferred Term
Term UI T001107686
Date06/08/2021
LexicalTag NON
ThesaurusID NLM (2022); Angiopoietin-related Protein 4
Term UI T000924132
Date05/11/2017
LexicalTag NON
ThesaurusID NLM (2018); ANGPTL4 Protein
Term UI T000924130
Date05/11/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Angiopoietin-Like Protein 4 MeSH Descriptor Data 2023