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Troglitazone
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Troglitazone
Tree Number(s)
D02.886.675.933.750
D03.383.129.708.933.750
D03.383.663.283.240.612
D03.633.100.150.240.612
Unique ID
D000077288
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077288
Scope Note
A chroman and thiazolidinedione derivative that acts as a
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
(
PPAR
) agonist. It was formerly used in the treatment of
TYPE 2 DIABETES MELLITUS
, but has been withdrawn due to hepatotoxicity.
Entry Term(s)
5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T
CS 045
CS-045
Prelay
Rezulin
Pharm Action
Hypoglycemic Agents
Related Numbers
97322-87-7
CAS Type 1 Name
2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-
Public MeSH Note
2019; TROGLITAZONE was indexed under CHROMANS and THIAZOLIDINEDIONES 2004-2018; and under THIAZOLES 1988-2003
History Note
2019 (1988)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/02/27
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analogs & derivatives (AA)
analysis (AN)
antagonists & inhibitors (AI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
economics (EC)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
urine (UR)
Organic Chemicals [D02]
Sulfur Compounds [D02.886]
Thiazoles [D02.886.675]
Thiazolidinediones [D02.886.675.933]
Pioglitazone [D02.886.675.933.250]
Rosiglitazone [D02.886.675.933.500]
Troglitazone [D02.886.675.933.750]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Azoles [D03.383.129]
Thiazoles [D03.383.129.708]
Thiazolidinediones [D03.383.129.708.933]
Pioglitazone [D03.383.129.708.933.250]
Rosiglitazone [D03.383.129.708.933.500]
Troglitazone [D03.383.129.708.933.750]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrans [D03.383.663]
Benzopyrans [D03.383.663.283]
Chromans [D03.383.663.283.240]
Benzoisochromanequinones [D03.383.663.283.240.095]
Catechin [D03.383.663.283.240.190]
Centchroman [D03.383.663.283.240.225]
Troglitazone [D03.383.663.283.240.612]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Benzopyrans [D03.633.100.150]
Chromans [D03.633.100.150.240]
Benzoisochromanequinones [D03.633.100.150.240.095]
Catechin [D03.633.100.150.240.190]
Centchroman [D03.633.100.150.240.225]
Troglitazone [D03.633.100.150.240.612]
Expand All
Collapse All
Troglitazone
Preferred
Concept UI
M000640328
Related Numbers
97322-87-7
Scope Note
A chroman and thiazolidinedione derivative that acts as a
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
(
PPAR
) agonist. It was formerly used in the treatment of
TYPE 2 DIABETES MELLITUS
, but has been withdrawn due to hepatotoxicity.
Terms
Troglitazone
Preferred Term
Term UI
T000938775
Date
01/05/2018
LexicalTag
NON
ThesaurusID
5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T
Term UI
T000938776
Date
01/05/2018
LexicalTag
NON
ThesaurusID
NLM (1988)
CS 045
Narrower
Concept UI
M0161287
Terms
CS 045
Preferred Term
Term UI
T191292
Date
01/01/1955
LexicalTag
LAB
ThesaurusID
NLM (1988)
CS-045
Term UI
T191293
Date
01/01/1955
LexicalTag
LAB
ThesaurusID
NLM (1988)
Rezulin
Narrower
Concept UI
M0161289
Terms
Rezulin
Preferred Term
Term UI
T191294
Date
01/01/1955
LexicalTag
TRD
ThesaurusID
Prelay
Narrower
Concept UI
M0398828
Terms
Prelay
Preferred Term
Term UI
T462343
Date
09/19/2001
LexicalTag
TRD
ThesaurusID
NLM (2001)
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