MeSH Browser

MeSH Heading: Medium Spiny Neurons
Tree Number(s): A08.675.289.500; A08.675.650.535; A11.671.285.500; A11.671.650.535
Unique ID: D000094242
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000094242
Scope Note: Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.
Entry Term(s): Striatal Medium-Sized Spiny Neurons
Previous Indexing: Corpus Striatum (1983-2022); Neurons (1983-2022)
See Also: Corpus Striatum
Public MeSH Note: 2023
History Note: 2023
Date Established: 2023/01/01
Date of Entry: 2022/07/12
Revision Date: 2022/07/12

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cytology (CY)

drug effects (DE)

enzymology (EN)

immunology (IM)

metabolism (ME)

microbiology (MI)

parasitology (PS)

pathology (PA)

physiology (PH)

radiation effects (RE)

transplantation (TR)

ultrastructure (UL)

virology (VI)

Medium Spiny Neurons MeSH Descriptor Data 2025