MeSH Browser

MeSH Heading: DNA Polymerase iota
Tree Number(s): D08.811.913.696.445.308.300.876.001
Unique ID: D000094769
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000094769
Scope Note: A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site.
Entry Term(s): POL iota; POLiota; RAD30B
Registry Numbers: EC 2.7.7.7
Public MeSH Note: 2023; was indexed as DNA-DIRECTED DNA POLYMERASE 2000-2022
History Note: 2023 (2000)
Date Introduced: 2023/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0372410
Registry Numbers: EC 2.7.7.7
Scope Note: A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site.
Terms: DNA Polymerase iota Preferred Term
Term UI T001120044
Date04/22/2022
LexicalTag NON
ThesaurusID NLM (2023); POL iota
Term UI T001120043
Date04/22/2022
LexicalTag ACX
ThesaurusID NLM (2023); POLiota
Term UI T001120042
Date04/22/2022
LexicalTag ACX
ThesaurusID NLM (2023); RAD30B
Term UI T428489
Date11/09/2000
LexicalTag NON
ThesaurusID NLM (2000)

DNA Polymerase iota MeSH Descriptor Data 2026