MeSH Browser

MeSH Heading: Polyether Polyketides
Tree Number(s): D02.355.291.933; D02.540.576.625; D04.345.241.654; D04.345.674.625
Unique ID: D000095662
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000095662
Scope Note: Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.
Entry Term(s): Marine Ladder Polyethers; Polyether Antibiotics; Polyether Ionophore Antibiotics; Polyether Ionophores
Public MeSH Note: 2024
History Note: 2024
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Polyether Polyketides MeSH Descriptor Data 2025