MeSH Browser

MeSH Heading: Perineuronal Nets
Tree Number(s): A11.284.295.310.775
Unique ID: D000099132
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099132
Scope Note: Meshwork of extracellular matrix containing CHONDROITIN SULFATE PROTEOGLYCANS structures interposed among glial processes. Perineuronal nets (PNN) surround the soma and dendrites of certain neuronal cell types, e.g., inhibitory GABAergic PARVALBUMIN-positive INTERNEURONS. PNN plays a role in NEURONAL PLASTICITY and may modulate memory.
Entry Term(s): Perineural Nets; Perineuronal Glial Nets; Perineuronal Proteoglycan Nets; Perinodal ECM; Perinodal Extracellular Matrix; Perisynaptic Nets
Previous Indexing: Extracellular Matrix (1993-2025)
Consider Also: Nerve Net
Public MeSH Note: 2026
History Note: 2026
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: chemistry (CH)

classification (CL)

drug effects (DE)

enzymology (EN)

genetics (GE)

immunology (IM)

metabolism (ME)

microbiology (MI)

parasitology (PS)

pathology (PA)

physiology (PH)

radiation effects (RE)

transplantation (TR)

ultrastructure (UL)

virology (VI)

Concept UI: M000768481
Scope Note: Meshwork of extracellular matrix containing CHONDROITIN SULFATE PROTEOGLYCANS structures interposed among glial processes. Perineuronal nets (PNN) surround the soma and dendrites of certain neuronal cell types, e.g., inhibitory GABAergic PARVALBUMIN-positive INTERNEURONS. PNN plays a role in NEURONAL PLASTICITY and may modulate memory.
Terms: Perineuronal Nets Preferred Term
Term UI T001146033
Date11/14/2024
LexicalTag NON
ThesaurusID NLM (2026); Perineural Nets
Term UI T001146038
Date11/14/2024
LexicalTag NON
ThesaurusID NLM (2026); Perineuronal Glial Nets
Term UI T001146032
Date11/14/2024
LexicalTag NON
ThesaurusID NLM (2026); Perineuronal Proteoglycan Nets
Term UI T001146034
Date11/14/2024
LexicalTag NON
ThesaurusID NLM (2026); Perisynaptic Nets
Term UI T001146035
Date11/14/2024
LexicalTag NON
ThesaurusID NLM (2026)

Perineuronal Nets MeSH Descriptor Data 2026