MeSH Browser

MeSH Heading: Eflornithine
Tree Number(s): D12.125.068.665.340; D12.125.095.765.340
Unique ID: D000518
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000518
Scope Note: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
Entry Term(s): DL-alpha-Difluoromethylornithine; Difluoromethylornithine; Eflornithine Hydrochloride; Eflornithine Monohydrochloride, Monohydrate; MDL-71,782 A; Ornidyl; RMI 71782; Vaniqa; alpha-Difluoromethyl Ornithine; alpha-Difluoromethylornithine
Pharm Action: Antineoplastic Agents
Trypanocidal Agents
Ornithine Decarboxylase Inhibitors
Related Numbers: 4NH22NDW9H; 67037-37-0; 70052-12-9; 96020-91-6
CAS Type 1 Name: Ornithine, 2-(difluoromethyl)-
Previous Indexing: Ornithine (1966-1974); Ornithine/analogs & derivatives (1975-1986)
Public MeSH Note: 1991; see ALPHA-DIFLUOROMETHYLORNITHINE 1987-1990
History Note: 1991; use ALPHA-DIFLUOROMETHYLORNITHINE 1987-1990
Date Established: 1987/01/01
Date of Entry: 1986/06/03
Revision Date: 2018/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0000787
Related Numbers: 4NH22NDW9H; 67037-37-0; 70052-12-9; 96020-91-6
Scope Note: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
Terms: Eflornithine Preferred Term
Term UI T001543
Date01/01/1999
LexicalTag NON
ThesaurusID; alpha-Difluoromethyl Ornithine
Term UI T001545
Date06/03/1986
LexicalTag NON
ThesaurusID UNK (19XX); Difluoromethylornithine
Term UI T001548
Date06/03/1986
LexicalTag NON
ThesaurusID; alpha-Difluoromethylornithine
Term UI T001542
Date03/19/1990
LexicalTag NON
ThesaurusID NLM (1991); DL-alpha-Difluoromethylornithine
Term UI T429688
Date11/28/2000
LexicalTag NON
ThesaurusID NLM (2002)

Eflornithine MeSH Descriptor Data 2025