MeSH Browser

MeSH Heading: Anesthetics, Local
Tree Number(s): D27.505.696.277.100.200; D27.505.696.663.850.025; D27.505.954.427.210.100.200
Unique ID: D000779
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000779
Annotation: see note at ANESTHETICS
Scope Note: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Entry Term(s): Anesthetics, Conduction-Blocking; Anesthetics, Topical; Conduction-Blocking Anesthetics; Local Anesthetic
NLM Classification #: QV 110
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0001169
Scope Note: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Terms: Anesthetics, Local Preferred Term
Term UI T002306
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Local Anesthetic
Term UI T001003316
Date12/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Anesthetics, Conduction-Blocking
Term UI T002307
Date06/19/1986
LexicalTag NON
ThesaurusID UNK (19XX); Conduction-Blocking Anesthetics
Term UI T002308
Date06/19/1986
LexicalTag NON
ThesaurusID UNK (19XX)

Anesthetics, Local MeSH Descriptor Data 2025