MeSH Browser

MeSH Heading: Argininosuccinate Synthase
Tree Number(s): D08.811.464.259.300
Unique ID: D001124
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001124
Annotation: /defic: consider also CITRULLINEMIA
Scope Note: An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Entry Term(s): Argininosuccinate Synthetase
Related Numbers: 9023-58-9
CAS Type 1 Name: L-Citrulline:L-aspartate ligase (AMP-forming)
Previous Indexing: Arginine (1973-1974); Ligases (1973-1974); Succinates (1973-1974)
See Also: Citrullinemia
Public MeSH Note: 98; see ARGININOSUCCINATE SYNTHETASE 1991-97; see LIGASES 1975-90
History Note: 98(75)
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Argininosuccinate Synthase MeSH Descriptor Data 2025