MeSH Browser

MeSH Heading: beta-N-Acetylhexosaminidases
Tree Number(s): D08.811.277.450.483.180
Unique ID: D001619
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001619
Annotation: do not confuse with ACETYLGLUCOSAMINIDASE; /‌defic: consider also TAY SACHS DISEASE and SANDHOFF DISEASE
Scope Note: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Entry Term(s): N-Acetyl-beta-D-hexosaminidase; beta-Hexosaminidase; beta-N-Acetyl-D-hexosaminidase; beta-N-Acetyl-hexosaminidase; beta-N-Acetylhexosaminidase
CAS Type 1 Name: beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Previous Indexing: Glycoside Hydrolases (1966-1970); Hexosaminidases (1971-1986)
See Also: Sandhoff Disease; Tay-Sachs Disease
Public MeSH Note: 2008; see BETA-N-ACETYL-D-HEXOSAMINIDASE 1988-2007
History Note: 2008(1988)
Date Established: 1987/01/01
Date of Entry: 1986/06/02
Revision Date: 2007/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0002423
Scope Note: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Terms: beta-N-Acetylhexosaminidases Preferred Term
Term UI T694278
Date03/23/2007
LexicalTag NON
ThesaurusID NLM (2008); N-Acetyl-beta-D-hexosaminidase
Term UI T004670
Date06/02/1986
LexicalTag NON
ThesaurusID UNK (19XX); beta-Hexosaminidase
Term UI T004669
Date06/02/1986
LexicalTag NON
ThesaurusID UNK (19XX); beta-N-Acetyl-D-hexosaminidase
Term UI T004671
Date06/02/1986
LexicalTag NON
ThesaurusID UNK (19XX); beta-N-Acetyl-hexosaminidase
Term UI T581427
Date04/06/2004
LexicalTag NON
ThesaurusID NLM (2005); beta-N-Acetylhexosaminidase
Term UI T004672
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1987)

beta-N-Acetylhexosaminidases MeSH Descriptor Data 2025