MeSH Browser

MeSH Heading: Neuromuscular Nondepolarizing Agents
Tree Number(s): D27.505.696.663.700.710.575
Unique ID: D003473
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003473
Scope Note: Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Entry Term(s): Curare-Like Agents; Curariform Drugs; Muscle Relaxants, Non-Depolarizing; Neuromuscular Blocking Agents, Competitive; Nondepolarizing Blockers
NLM Classification #: QV 140
Previous Indexing: Muscles (1966-1969)
See Also: Nicotinic Antagonists
Public MeSH Note: 93; was CURARE-LIKE AGENTS 1970-92; MUSCLE RELAXANTS, POLARIZING was see NEUROMUSCULAR NONDEPOLARIZING AGENTS 1989-94; NEUROMUSCULAR NONDEPOLARIZING AGENTS & PACHYCURARES were see CURARE-LIKE AGENTS 1970-92; CURARIFORM DRUGS was see MUSCLE RELAXANTS 1963-69; MUSCLE RELAXANTS was see under CURARE-LIKE AGENTS & MUSCLE RELAXANTS, CENTRAL & NEUROMUSCULAR DEPOLARIZING AGENTS 1970-74, was heading 1963-69; CURARIFORM ANTAGONISTS was heading 1963-69
Online Note: use NEUROMUSCULAR NONDEPOLARIZING AGENTS to search MUSCLE RELAXANTS, POLARIZING 1989-94 & CURARE-LIKE AGENTS & PACHYCURARES 1970-92; search MUSCLE RELAXANTS under NEUROMUSCULAR NONDEPOLARIZING AGENTS, MUSCLE RELAXANTS, CENTRAL & NEUROMUSCULAR DEPOLARIZING AGENTS 1970-74 & MUSCLES 1966-69; search CURARIFORM ANTAGONISTS under CURARE 1966-69
History Note: 93; was CURARE-LIKE AGENTS 1970-92; MUSCLE RELAXANTS, POLARIZING was see NEUROMUSCULAR NONDEPOLARIZING AGENTS 1989-94; NEUROMUSCULAR NONDEPOLARIZING AGENTS & PACHYCURARES were see CURARE-LIKE AGENTS 1975-92; CURARIFORM DRUGS was see under MUSCLE RELAXANTS 1963-69; MUSCLE RELAXANTS was see under CURARE-LIKE AGENTS & MUSCLE RELAXANTS, CENTRAL & NEUROMUSCULAR DEPOLARIZING AGENTS 1970-74, was heading 1963-69; CURARIFORM ANTAGONISTS was heading 1963-69
Date Established: 1970/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Peripheral Nervous System Agents [D27.505.696.663]
      - Neuromuscular Agents [D27.505.696.663.700]
        
        Neuromuscular Blocking Agents [D27.505.696.663.700.710]
        
        Neuromuscular Depolarizing Agents [D27.505.696.663.700.710.550]
        
        Neuromuscular Nondepolarizing Agents [D27.505.696.663.700.710.575]

Neuromuscular Nondepolarizing Agents Preferred

Concept UI: M0005420
Scope Note: Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Terms: Neuromuscular Nondepolarizing Agents Preferred Term
Term UI T010090
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1970); Curare-Like Agents
Term UI T010087
Date02/26/1992
LexicalTag NON
ThesaurusID NLM (1993); Curariform Drugs
Term UI T010088
Date03/29/1974
LexicalTag NON
ThesaurusID UNK (19XX); Muscle Relaxants, Non-Depolarizing
Term UI T010089
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); Neuromuscular Blocking Agents, Competitive
Term UI T010091
Date02/26/1992
LexicalTag NON
ThesaurusID NLM (1993); Nondepolarizing Blockers
Term UI T010092
Date02/14/1994
LexicalTag NON
ThesaurusID NLM (1995)

Neuromuscular Nondepolarizing Agents MeSH Descriptor Data 2025