MeSH Browser

MeSH Heading: Dianhydrogalactitol
Tree Number(s): D02.033.800.400.350; D09.853.400.350
Unique ID: D003961
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003961
Scope Note: One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
Entry Term(s): 1,2,5,6-Dianhydrogalactitol; 1,2-5,6-Dianhydrogalactitol; Dianhydrodulcitol; Diepoxydulcitol; Diepoxygalactitol; NSC-132313
Pharm Action: Antineoplastic Agents, Alkylating
Registry Numbers: 4S465RYF7M; 0
Related Numbers: 23261-20-3
CAS Type 1 Name: Galactitol, 1,2:5,6-dianhydro-
Previous Indexing: Alcohols (1966-1971); Dulcitol (1972-1978); Ethers, Cyclic (1966-1978)
Public MeSH Note: 91; was see under SUGAR ALCOHOLS 1979-90
History Note: 91(79); was see under SUGAR ALCOHOLS 1979-90
Date Established: 1991/01/01
Date of Entry: 1978/02/07
Revision Date: 2018/07/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0006206
Registry Numbers: 4S465RYF7M
Related Numbers: 23261-20-3
Scope Note: One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
Terms: Dianhydrogalactitol Preferred Term
Term UI T012002
Date01/01/1999
LexicalTag NON
ThesaurusID; Dianhydrodulcitol
Term UI T012001
Date02/07/1978
LexicalTag NON
ThesaurusID UNK (19XX); Diepoxydulcitol
Term UI T012003
Date02/07/1978
LexicalTag NON
ThesaurusID UNK (19XX); Diepoxygalactitol
Term UI T012004
Date02/07/1978
LexicalTag NON
ThesaurusID UNK (19XX); 1,2,5,6-Dianhydrogalactitol
Term UI T012000
Date08/30/1982
LexicalTag NON
ThesaurusID UNK (19XX); 1,2-5,6-Dianhydrogalactitol
Term UI T000941632
Date03/28/2018
LexicalTag NON
ThesaurusID NLM (2017)

Dianhydrogalactitol MeSH Descriptor Data 2025