MeSH Browser

MeSH Heading: Diphosphonates
Tree Number(s): D02.705.429.500
Unique ID: D004164
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004164
Scope Note: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Entry Term(s): Bisphosphonate; Bisphosphonates
Pharm Action: Bone Density Conservation Agents
Previous Indexing: Organophosphorus Compounds (1971-1976); Phosphonic Acids (1966-1976)
Public MeSH Note: 77
History Note: 77
Date Established: 1977/01/01
Date of Entry: 1976/04/16
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Diphosphonates MeSH Descriptor Data 2025