MeSH Browser

MeSH Heading: Dosage Compensation, Genetic
Tree Number(s): G05.308.203.249
Unique ID: D004303
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004303
Annotation: do not confuse with GENE DOSAGE
Scope Note: Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Entry Term(s): Dosage Compensation (Genetics); Gene Dosage Compensation; Hypertranscription, X-Chromosome; X-Chromosome Hypertranscription
Previous Indexing: Sex Chromosomes (1968-1981); X Chromosome (1978-1981)
Public MeSH Note: 2006; see DOSAGE COMPENSATION (GENETICS) 1982-2005
History Note: 2006 (1982)
Date Established: 1982/01/01
Date of Entry: 1981/02/23
Revision Date: 2016/06/17

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0006764
Scope Note: Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Terms: Dosage Compensation, Genetic Preferred Term
Term UI T606397
Date08/26/2004
LexicalTag NON
ThesaurusID NLM (2006); Dosage Compensation (Genetics)
Term UI T013154
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1982); Gene Dosage Compensation
Term UI T606417
Date08/26/2004
LexicalTag NON
ThesaurusID NLM (2006)

Dosage Compensation, Genetic MeSH Descriptor Data 2025