MeSH Browser

MeSH Heading: Glucose-6-Phosphate Isomerase
Tree Number(s): D08.811.399.475.200.350
Unique ID: D005956
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005956
Scope Note: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Entry Term(s): Autocrine Motility Factor; Glucosephosphate Isomerase; Isomerase, Glucose 6 Phosphate; Neuroleukin; Phosphoglucose Isomerase; Phosphohexose Isomerase; Tumor Autocrine Motility Factor; Tumor-Cell Autocrine Motility Factor
Related Numbers: EC 5.3.1.9
CAS Type 1 Name: D-Glucose-6-phosphate ketol-isomerase
Public MeSH Note: 1998; see GLUCOSEPHOSPHATE ISOMERASE 1965-1997; for AUTOCRINE MOTILITY FACTOR see AUTOCRINE MOTILITY FACTOR 1992-2011; for NEUROLEUKIN see NEUROLEUKIN 1990-2011
History Note: 1998(1965)
Entry Combination: deficiency:Anemia, Hemolytic, Congenital Nonspherocytic
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/07/01

Entry Combination: deficiency:Anemia, Hemolytic, Congenital Nonspherocytic
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Isomerases [D08.811.399]
    - Intramolecular Oxidoreductases [D08.811.399.475]
      - Aldose-Ketose Isomerases [D08.811.399.475.200]
        
        Glucose-6-Phosphate Isomerase [D08.811.399.475.200.350]
        
        Mannose-6-Phosphate Isomerase [D08.811.399.475.200.550]
        
        Triose-Phosphate Isomerase [D08.811.399.475.200.775]

Glucose-6-Phosphate Isomerase Preferred

Concept UI: M0009354
Related Numbers: EC 5.3.1.9
Scope Note: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Terms: Glucose-6-Phosphate Isomerase Preferred Term
Term UI T018044
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1965); Glucosephosphate Isomerase
Term UI T018045
Date11/08/1996
LexicalTag NON
ThesaurusID NLM (1998); Isomerase, Glucose 6 Phosphate
Term UI T018043
Date06/13/1988
LexicalTag NON
ThesaurusID UNK (19XX); Phosphoglucose Isomerase
Term UI T018047
Date04/26/1977
LexicalTag NON
ThesaurusID UNK (19XX); Phosphohexose Isomerase
Term UI T018046
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Autocrine Motility Factor Narrower

Concept UI: M0025255
Scope Note: A secreted form of glucose-6-phosphate isomerase.
Terms: Autocrine Motility Factor Preferred Term
Term UI T049525
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1992); Neuroleukin
Term UI T046804
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Tumor Autocrine Motility Factor
Term UI T049526
Date09/20/1990
LexicalTag NON
ThesaurusID NLM (1992); Tumor-Cell Autocrine Motility Factor
Term UI T049527
Date09/20/1990
LexicalTag NON
ThesaurusID NLM (1992)

Glucose-6-Phosphate Isomerase MeSH Descriptor Data 2025