MeSH Browser

MeSH Heading: Histamine H2 Antagonists
Tree Number(s): D27.505.519.625.375.425.425; D27.505.696.577.375.425.425
Unique ID: D006635
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006635
Scope Note: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Entry Version: HISTAMINE H2 ANTAG
Entry Term(s): Antagonists, Histamine H2; Antihistaminics, H2; Blockaders, Histamine H2 Receptor; H2 Receptor Blockader; H2 Receptor Blockaders; Histamine H2 Antagonist; Histamine H2 Blocker; Histamine H2 Blockers; Histamine H2 Receptor Antagonist; Histamine H2 Receptor Antagonists; Histamine H2 Receptor Blockader; Histamine H2 Receptor Blockaders; Receptor Antagonists, Histamine H2; Receptor Blockaders, H2
NLM Classification #: QV 157
See Also: Anti-Ulcer Agents
Public MeSH Note: 95; was HISTAMINE H2 RECEPTOR BLOCKADERS 1977-94
Online Note: use HISTAMINE H2 ANTAGONISTS to search HISTAMINE H2 RECEPTOR BLOCKADERS 1977-94
History Note: 95; was HISTAMINE H2 RECEPTOR BLOCKADERS 1977-94
Date Established: 1977/01/01
Date of Entry: 1976/05/05
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Neurotransmitter Agents [D27.505.519.625]
      - Histamine Agents [D27.505.519.625.375]
        
        Histamine Antagonists [D27.505.519.625.375.425]
        
        Histamine H1 Antagonists [D27.505.519.625.375.425.400]
        
        Histamine H2 Antagonists [D27.505.519.625.375.425.425]
        
        Histamine H3 Antagonists [D27.505.519.625.375.425.712]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Neurotransmitter Agents [D27.505.696.577]
      - Histamine Agents [D27.505.696.577.375]
        
        Histamine Antagonists [D27.505.696.577.375.425]
        
        Histamine H1 Antagonists [D27.505.696.577.375.425.400]
        
        Histamine H2 Antagonists [D27.505.696.577.375.425.425]
        
        Histamine H3 Antagonists [D27.505.696.577.375.425.712]

Histamine H2 Antagonists Preferred

Concept UI: M0010396
Scope Note: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Terms: Histamine H2 Antagonists Preferred Term
Term UI T019988
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); H2 Receptor Blockaders
Term UI T019980
Date02/10/1984
LexicalTag NON
ThesaurusID UNK (19XX); Histamine H2 Antagonist
Term UI T000998798
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); H2 Receptor Blockader
Term UI T000998799
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Receptor Blockaders, H2
Term UI T019981
Date11/20/1989
LexicalTag NON
ThesaurusID NLM (1990); Blockaders, Histamine H2 Receptor
Term UI T019982
Date05/03/1994
LexicalTag NON
ThesaurusID NLM (1995); Histamine H2 Receptor Blockaders
Term UI T019983
Date01/28/1994
LexicalTag NON
ThesaurusID NLM (1995); Antihistaminics, H2
Term UI T019984
Date04/23/1990
LexicalTag NON
ThesaurusID NLM (1991); Receptor Antagonists, Histamine H2
Term UI T019985
Date05/03/1994
LexicalTag NON
ThesaurusID NLM (1995); Histamine H2 Receptor Antagonists
Term UI T019986
Date03/30/1992
LexicalTag NON
ThesaurusID NLM (1993); Antagonists, Histamine H2
Term UI T019987
Date05/03/1994
LexicalTag NON
ThesaurusID NLM (1995); Histamine H2 Blockers
Term UI T019989
Date01/28/1994
LexicalTag NON
ThesaurusID NLM (1995); Histamine H2 Blocker
Term UI T000998800
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Histamine H2 Receptor Antagonist
Term UI T000998797
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Histamine H2 Receptor Blockader
Term UI T000998801
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021)

Histamine H2 Antagonists MeSH Descriptor Data 2025