MeSH Browser

MeSH Heading: Iduronate Sulfatase
Tree Number(s): D08.811.277.352.827.500
Unique ID: D007066
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007066
Scope Note: An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demonstrated in Hunter's syndrome, which is characterized by an excess of dermatan sulfate and heparan sulfate. EC 3.1.6.13.
Entry Term(s): Hunter Corrective Factor; Iduronate Sulfate Sulfatase; Iduronatesulfate Sulfohydrolase; Sulfoiduronate Sulfatase
CAS Type 1 Name: L-Iduronate-2-sulfate 2-sulfohydrolase
Previous Indexing: Iduronic Acid (1975); Sulfatases (1972-1975); Uronic Acids (1972-1975)
See Also: Mucopolysaccharidosis II
Public MeSH Note: 91; was see under SULFATASES 1976-90
History Note: 91(76); was see under SULFATASES 1976-90
Entry Combination: deficiency:Mucopolysaccharidosis II
Date Established: 1991/01/01
Date of Entry: 1975/07/25
Revision Date: 2009/07/06

Entry Combination: deficiency:Mucopolysaccharidosis II
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0010995
Scope Note: An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demonstrated in Hunter's syndrome, which is characterized by an excess of dermatan sulfate and heparan sulfate. EC 3.1.6.13.
Terms: Iduronate Sulfatase Preferred Term
Term UI T021143
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1976); Hunter Corrective Factor
Term UI T021142
Date07/22/1975
LexicalTag EPO
ThesaurusID UNK (19XX); Iduronate Sulfate Sulfatase
Term UI T021144
Date10/02/1984
LexicalTag NON
ThesaurusID UNK (19XX); Iduronatesulfate Sulfohydrolase
Term UI T021145
Date07/22/1975
LexicalTag NON
ThesaurusID UNK (19XX); Sulfoiduronate Sulfatase
Term UI T021146
Date07/22/1975
LexicalTag NON
ThesaurusID UNK (19XX)

Iduronate Sulfatase MeSH Descriptor Data 2025