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Methylation MeSH Descriptor Data 2026

MeSH Heading: Methylation
Tree Number(s): G02.111.035.538; G02.607.094.538; G03.059.538
Unique ID: D008745
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008745
Annotation: almost never IM; enzymatic methylation: coord NIM with METHYLTRANSFERASES (IM) + substrate (NIM) or specific methyltransferase (IM); DNA METHYLATION is also available
Scope Note: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
Public MeSH Note: 68
History Note: 68
Date Introduced: 1968/01/01
Last Updated: 2016/06/30

Allowable Qualifiers: drug effects (DE)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Alkylation [G02.111.035]
    - Methylation [G02.111.035.538]
      - DNA Methylation [G02.111.035.538.161]
      - RNA Methylation [G02.111.035.538.580]

Chemical Phenomena [G02]
- Organic Chemistry Phenomena [G02.607]
  - Alkylation [G02.607.094]
    - Methylation [G02.607.094.538]
      - RNA Methylation [G02.607.094.538.500]

Metabolism [G03]
- Alkylation [G03.059]
  - Methylation [G03.059.538]
    - DNA Methylation [G03.059.538.161]
    - RNA Methylation [G03.059.538.580]

Methylation Preferred

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