MeSH Browser

MeSH Heading: Mucopolysaccharidosis IV
Tree Number(s): C16.320.565.202.715.655; C16.320.565.595.600.655; C17.300.550.575.655; C18.452.648.202.715.655; C18.452.648.595.600.655
Unique ID: D009085
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009085
Scope Note: Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.
Entry Version: MPS IV
Entry Term(s): Eccentro-Osteochondrodysplasia; Eccentroosteochondrodysplasia; GALNS Deficiency; Galactosamine-6-Sulfatase Deficiency; MPS IV A; MPS IV B; MPS IVA; MPS IVB; Morquio A Disease; Morquio B Syndrome; Morquio Disease; Morquio Syndrome; Morquio Syndrome A; Morquio Syndrome B; Morquio Syndrome, Type B; Morquio's Disease; Morquio's Disease Type B; Morquio's Syndrome; Morquio-B Disease; Mucopolysaccharidosis 4; Mucopolysaccharidosis 4B; Mucopolysaccharidosis Type IV; Mucopolysaccharidosis Type IV A; Mucopolysaccharidosis Type IV B; Mucopolysaccharidosis Type IVA; Mucopolysaccharidosis Type IVB
Public MeSH Note: 1992; see MUCOPOLYSACCHARIDOSIS 4 1980-1991, see ECCENTROOSTEOCHONDRODYSPLASIA 1963-1979; MORQUIO'S DISEASE was MORQUIO DISEASE see MUCOPOLYSACCHARIDOSIS 4 1980-1991
History Note: 1992; use MUCOPOLYSACCHARIDOSIS 4 1980-1991, use ECCENTROOSTEOCHONDRODYSPLASIA 1963-1979; for MORQUIO'S DISEASE use MUCOPOLYSACCHARIDOSIS 4 1980-1991
Date Established: 1992/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Carbohydrate Metabolism, Inborn Errors [C16.320.565.202]
      - Mucopolysaccharidoses [C16.320.565.202.715]
        
        Mucopolysaccharidosis I [C16.320.565.202.715.640]
        
        Mucopolysaccharidosis II [C16.320.565.202.715.645]
        
        Mucopolysaccharidosis III [C16.320.565.202.715.650]
        
        Mucopolysaccharidosis IV [C16.320.565.202.715.655]
        
        Mucopolysaccharidosis VI [C16.320.565.202.715.670]
        
        Mucopolysaccharidosis VII [C16.320.565.202.715.675]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lysosomal Storage Diseases [C16.320.565.595]
      - Mucopolysaccharidoses [C16.320.565.595.600]
        
        Mucopolysaccharidosis I [C16.320.565.595.600.640]
        
        Mucopolysaccharidosis II [C16.320.565.595.600.645]
        
        Mucopolysaccharidosis III [C16.320.565.595.600.650]
        
        Mucopolysaccharidosis IV [C16.320.565.595.600.655]
        
        Mucopolysaccharidosis VI [C16.320.565.595.600.670]
        
        Mucopolysaccharidosis VII [C16.320.565.595.600.675]

Skin and Connective Tissue Diseases [C17]
- Connective Tissue Diseases [C17.300]
  - Mucinoses [C17.300.550]
    - Mucopolysaccharidoses [C17.300.550.575]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Carbohydrate Metabolism, Inborn Errors [C18.452.648.202]
      - Mucopolysaccharidoses [C18.452.648.202.715]
        
        Mucopolysaccharidosis I [C18.452.648.202.715.640]
        
        Mucopolysaccharidosis II [C18.452.648.202.715.645]
        
        Mucopolysaccharidosis III [C18.452.648.202.715.650]
        
        Mucopolysaccharidosis IV [C18.452.648.202.715.655]
        
        Mucopolysaccharidosis VI [C18.452.648.202.715.670]
        
        Mucopolysaccharidosis VII [C18.452.648.202.715.675]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lysosomal Storage Diseases [C18.452.648.595]
      - Mucopolysaccharidoses [C18.452.648.595.600]
        
        Mucopolysaccharidosis I [C18.452.648.595.600.640]
        
        Mucopolysaccharidosis II [C18.452.648.595.600.645]
        
        Mucopolysaccharidosis III [C18.452.648.595.600.650]
        
        Mucopolysaccharidosis IV [C18.452.648.595.600.655]
        
        Mucopolysaccharidosis VI [C18.452.648.595.600.670]
        
        Mucopolysaccharidosis VII [C18.452.648.595.600.675]

Mucopolysaccharidosis IV Preferred

Concept UI: M0014173
Scope Note: Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.
Terms: Mucopolysaccharidosis IV Preferred Term
Term UI T027155
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Eccentro-Osteochondrodysplasia
Term UI T027152
Date05/31/1979
LexicalTag NON
ThesaurusID UNK (19XX); Eccentroosteochondrodysplasia
Term UI T027158
Date06/12/1979
LexicalTag NON
ThesaurusID UNK (19XX); Morquio Disease
Term UI T027153
Date10/18/1990
LexicalTag EPO
ThesaurusID; Morquio Syndrome
Term UI T843593
Date05/03/2013
LexicalTag NON
ThesaurusID GHR (2014); Morquio's Disease
Term UI T027154
Date09/12/1990
LexicalTag EPO
ThesaurusID; Morquio's Syndrome
Term UI T027156
Date09/12/1990
LexicalTag EPO
ThesaurusID; Mucopolysaccharidosis 4
Term UI T027157
Date09/12/1990
LexicalTag NON
ThesaurusID NLM (1992); Mucopolysaccharidosis Type IV
Term UI T843592
Date05/03/2013
LexicalTag NON
ThesaurusID GHR (2014)

Mucopolysaccharidosis Type IV A Narrower

Concept UI: M0014174
Terms: Mucopolysaccharidosis Type IV A Preferred Term
Term UI T757855
Date09/16/2009
LexicalTag NON
ThesaurusID NLM (2011); Galactosamine-6-Sulfatase Deficiency
Term UI T752828
Date06/16/2009
LexicalTag NON
ThesaurusID; Mucopolysaccharidosis Type IVA
Term UI T757856
Date09/16/2009
LexicalTag NON
ThesaurusID; Morquio Syndrome A
Term UI T752829
Date06/16/2009
LexicalTag EPO
ThesaurusID; MPS IV A
Term UI T753472
Date06/26/2009
LexicalTag ABB
ThesaurusID; MPS IVA
Term UI T753470
Date06/26/2009
LexicalTag ABB
ThesaurusID; Morquio A Disease
Term UI T812017
Date11/15/2011
LexicalTag EPO
ThesaurusID OMIM (2013)

Mucopolysaccharidosis Type IV B Narrower

Concept UI: M0014175
Terms: Mucopolysaccharidosis Type IV B Preferred Term
Term UI T757857
Date09/16/2009
LexicalTag NON
ThesaurusID; Morquio B Syndrome
Term UI T769316
Date04/14/2010
LexicalTag EPO
ThesaurusID; Morquio Syndrome B
Term UI T769317
Date04/14/2010
LexicalTag EPO
ThesaurusID; Morquio Syndrome, Type B
Term UI T769315
Date04/14/2010
LexicalTag EPO
ThesaurusID; Morquio's Disease Type B
Term UI T769314
Date04/14/2010
LexicalTag EPO
ThesaurusID; Morquio-B Disease
Term UI T769313
Date04/14/2010
LexicalTag EPO
ThesaurusID; MPS IV B
Term UI T753473
Date06/26/2009
LexicalTag ABB
ThesaurusID; MPS IVB
Term UI T825072
Date06/27/2012
LexicalTag ABB
ThesaurusID OMIM (2013); Mucopolysaccharidosis 4B
Term UI T741078
Date02/24/2009
LexicalTag NON
ThesaurusID; Mucopolysaccharidosis Type IVB
Term UI T757858
Date09/16/2009
LexicalTag NON
ThesaurusID

GALNS Deficiency Related

Mucopolysaccharidosis IV MeSH Descriptor Data 2025