MeSH Browser

MeSH Heading: Naltrexone
Tree Number(s): D03.132.577.249.706.550; D03.605.497.750.550; D03.633.400.686.750.550; D04.615.723.795.706.550
Unique ID: D009271
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009271
Scope Note: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Entry Term(s): Antaxone; Celupan; EN-1639A; Nalorex; Naltrexone Hydrochloride; Nemexin; ReVia; Trexan
Pharm Action: Alcohol Deterrents
Narcotic Antagonists
Registry Number: 5S6W795CQM
Related Numbers: 16590-41-3; Z6375YW9SF
CAS Type 1 Name: Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-
NLM Classification #: QV 89
Previous Indexing: Cyclopropanes (1973-1975); Morphinans (1973-1974); Naloxone/analogs & derivatives (1975)
Public MeSH Note: 1986; NALTREXONE was indexed under NALOXONE 1976-1985
History Note: 1986 (1976)
Date Established: 1986/01/01
Date of Entry: 1975/07/23
Revision Date: 2018/04/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Naltrexone MeSH Descriptor Data 2023