Because of a lapse in government funding, the information on this
website may not be up to date, transactions submitted via the
website may not be processed, and the agency may not be able to
respond to inquiries until appropriations are enacted. The NIH
Clinical Center (the research hospital of NIH) is open. For more
details about its operating status, please visit
cc.nih.gov. Updates
regarding government operating status and resumption of normal
operations can be found at
opm.gov.
Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
Entry Term(s)
Central Nervous System Syphilis
General Paralysis
General Paralysis of the Insane
General Paresis
General Paresis of the Insane
Juvenile Paresis
Neurosyphilis, Asymptomatic
Neurosyphilis, Gummatous
Neurosyphilis, Juvenile
Neurosyphilis, Secondary
Neurosyphilis, Symptomatic
Paralysis, General
Paretic Neurosyphilis
Secondary Neurosyphilis
Syphilis, CNS
Syphilis, Central Nervous System
NLM Classification #
WC 165
Public MeSH Note
1966; for GENERAL PARALYSIS & PARALYSIS, GENERAL see PARESIS 1963-93
History Note
1963; for GENERAL PARALYSIS & PARALYSIS, GENERAL use PARESIS 1963-93
Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)