MeSH Browser

MeSH Heading: Phenobarbital
Tree Number(s): D03.383.742.698.253.650
Unique ID: D010634
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D010634
Scope Note: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Entry Term(s): Gardenal; Hysteps; Luminal; Phenemal; Phenobarbital Sodium; Phenobarbital, Monosodium Salt; Phenobarbitone; Phenylbarbital; Phenylethylbarbituric Acid
Pharm Action: Anticonvulsants
Hypnotics and Sedatives
Excitatory Amino Acid Antagonists
GABA Modulators
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP3A Inducers
Related Numbers: 50-06-6; 57-30-7; SW9M9BB5K3
CAS Type 1 Name: 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-
NLM Classification #: QV 88
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0016514
Related Numbers: 50-06-6; 57-30-7; SW9M9BB5K3
Scope Note: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Terms: Phenobarbital Preferred Term
Term UI T031408
Date01/01/1999
LexicalTag NON
ThesaurusID; Phenemal
Term UI T031407
Date12/30/1976
LexicalTag NON
ThesaurusID UNK (19XX); Phenobarbitone
Term UI T031409
Date12/30/1976
LexicalTag NON
ThesaurusID UNK (19XX); Phenylethylbarbituric Acid
Term UI T031410
Date02/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); Phenylbarbital
Term UI T031411
Date12/30/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Phenobarbital MeSH Descriptor Data 2025