NLM Logo

Phenytoin MeSH Descriptor Data 2023


MeSH Heading
Phenytoin
Tree Number(s)
D03.383.129.308.432.555.730
Unique ID
D010672
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D010672
Scope Note
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Entry Term(s)
5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Antisacer
Difenin
Dihydan
Dilantin
Diphenylhydantoin
Epamin
Epanutin
Fenitoin
Hydantol
Phenhydan
Phenytoin Sodium
Sodium Diphenylhydantoinate
Pharm Action
Anticonvulsants
Voltage-Gated Sodium Channel Blockers
Cytochrome P-450 CYP1A2 Inducers
Registry Number
6158TKW0C5
Related Numbers
4182431BJH
57-41-0
CAS Type 1 Name
2,4-Imidazolidinedione, 5,5-diphenyl-
NLM Classification #
QV 85
Public MeSH Note
78; was DIPHENYLHYDANTOIN 1963-77
Online Note
use PHENYTOIN to search DIPHENYLHYDANTOIN 1966-77
History Note
78; was DIPHENYLHYDANTOIN 1963-77
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2021/07/01
Phenytoin Preferred
Difenin Narrower
Dihydan Narrower
Phenhydan Narrower
Epamin Narrower
Epanutin Narrower
Hydantol Narrower
Phenytoin Sodium Narrower
Antisacer Narrower
Dilantin Related
page delivered in 0.168s