MeSH Browser

MeSH Heading: Pregnanolone
Tree Number(s): D04.210.500.745.640
Unique ID: D011280
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011280
Annotation: do not confuse with PREGNENOLONE
Scope Note: A pregnane found in the urine of PREGNANT PEOPLE and sows. It has anesthetic, hypnotic, and sedative properties.
Entry Term(s): 3 alpha, 5 beta-Tetrahydroprogesterone; 3 alpha-Hydroxy-5 alpha-pregnan-20-one; 3 alpha-Hydroxy-5 beta-pregnan-20-one; 3-Hydroxypregnan-20-one; 3beta-Hydroxy-5alpha-pregnan-20-one; Allopregnan-3 beta-ol-20-one; Allopregnanolone; Eltanolone; Epipregnanolone; Pregnan-3alpha-ol-20-one; Pregnanolone, (3alpha)-isomer; Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer; Pregnanolone, (3alpha,5alpha)-isomer; Pregnanolone, (3alpha,5beta)-isomer; Pregnanolone, (3beta)-isomer; Pregnanolone, (3beta, 5alpha)-isomer; Pregnanolone, (3beta, 5alpha, 17alpha)-isomer; Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer; Pregnanolone, (3beta, 5beta)-isomer; Pregnanolone, (3beta, 5beta, 17alpha)-isomer; Pregnanolone, (3beta, 5beta,14beta)-isomer; Pregnanolone, (5alpha)-isomer; Sepranolone
Pharm Action: Anesthetics
Related Numbers: 128-20-1; 3P8Z6V53MU; 516-54-1; 516-55-2
CAS Type 1 Name: Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-
Previous Indexing: Hydroxysteroids (1972-1974); Ketosteroids (1972-1974); Pregnanes (1969-1974)
Public MeSH Note: 91; was see under PREGNANES 1975-90
History Note: 91(75); was see under PREGNANES 1975-90
Date Established: 1991/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/08/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Polycyclic Compounds [D04]
- Fused-Ring Compounds [D04.210]
  - Steroids [D04.210.500]
    - Pregnanes [D04.210.500.745]

Pregnanolone Preferred

Concept UI: M0017509
Related Numbers: 128-20-1; 3P8Z6V53MU; 516-54-1; 516-55-2
Scope Note: A pregnane found in the urine of PREGNANT PEOPLE and sows. It has anesthetic, hypnotic, and sedative properties.
Terms: Pregnanolone Preferred Term
Term UI T033247
Date01/01/1999
LexicalTag NON
ThesaurusID; 3 alpha-Hydroxy-5 beta-pregnan-20-one
Term UI T033245
Date02/08/1989
LexicalTag NON
ThesaurusID NLM (1989); 3 alpha, 5 beta-Tetrahydroprogesterone
Term UI T033244
Date09/30/1986
LexicalTag NON
ThesaurusID UNK (19XX); 3-Hydroxypregnan-20-one
Term UI T033246
Date09/30/1986
LexicalTag NON
ThesaurusID UNK (19XX); Eltanolone
Term UI T033248
Date11/14/1996
LexicalTag NON
ThesaurusID; Pregnan-3alpha-ol-20-one
Term UI T420751
Date08/04/2000
LexicalTag NON
ThesaurusID NLM (2002); Pregnanolone, (3alpha,5beta)-isomer
Term UI T420767
Date08/04/2000
LexicalTag NON
ThesaurusID NLM (2002)

Pregnanolone, (3beta)-isomer Related

Pregnanolone, (3beta, 5beta)-isomer Related

Pregnanolone, (3beta, 5alpha)-isomer Related

Concept UI: M0329751
Terms: Pregnanolone, (3beta, 5alpha)-isomer Preferred Term
Term UI T359945
Date09/13/1999
LexicalTag NON
ThesaurusID NLM (1999); 3beta-Hydroxy-5alpha-pregnan-20-one
Term UI T033249
Date11/02/1990
LexicalTag NON
ThesaurusID NLM (1992); Allopregnan-3 beta-ol-20-one
Term UI T420790
Date08/04/2000
LexicalTag NON
ThesaurusID NLM (2002); Sepranolone
Term UI T839247
Date03/26/2013
LexicalTag NON
ThesaurusID

Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer Narrower

Pregnanolone, (3beta, 5alpha, 17alpha)-isomer Related

Pregnanolone, (3beta, 5beta,14beta)-isomer Narrower

Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer Related

Pregnanolone, (3alpha)-isomer Related

Pregnanolone, (5alpha)-isomer Related

Pregnanolone, (3beta, 5beta, 17alpha)-isomer Related

Allopregnanolone Narrower

Pregnanolone MeSH Descriptor Data 2025