MeSH Browser

MeSH Heading: Progeria
Tree Number(s): C16.320.488.875; C16.320.565.753; C18.452.648.753
Unique ID: D011371
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011371
Scope Note: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Entry Term(s): Hutchinson Gilford Progeria Syndrome; Hutchinson-Gilford Progeria Syndrome; Hutchinson-Gilford Syndrome
NLM Classification #: WS 104
See Also: Cockayne Syndrome; Werner Syndrome
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/02/21

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0017668
Scope Note: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Terms: Progeria Preferred Term
Term UI T033535
Date01/01/1999
LexicalTag NON
ThesaurusID; Hutchinson Gilford Progeria Syndrome
Term UI T834214
Date12/12/2012
LexicalTag NON
ThesaurusID ORD (2010); Hutchinson-Gilford Progeria Syndrome
Term UI T811837
Date11/15/2011
LexicalTag NON
ThesaurusID; Hutchinson-Gilford Syndrome
Term UI T033534
Date01/01/1975
LexicalTag EPO
ThesaurusID

Progeria MeSH Descriptor Data 2023