MeSH Browser

MeSH Heading: Retrograde Degeneration
Tree Number(s): C23.550.737.500
Unique ID: D012183
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012183
Scope Note: Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
Entry Term(s): Axon Reaction; Axonal Reaction; Nissl Degeneration; Retrograde Degeneration, Transneuronal; Trans-Synaptic Degeneration
Public MeSH Note: 91; was see under NERVE DEGENERATION 1975-90; NISSL DEGENERATION was see NERVE DEGENERATION 1997, was heading 1975-96 (see under NERVE DEGENERATION 1975-90)
Online Note: use NERVE DEGENERATION to search NISSL DEGENERATION 1975-97 & RETROGRADE DEGENERATION 1967-74
History Note: 91(75); was see under NERVE DEGENERATION 1975-90; NISSL DEGENERATION was see NERVE DEGENERATION 1997, was heading 1975-96 (see under NERVE DEGENERATION 1975-90)
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 1999/11/26

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

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congenital (CN)

diagnosis (DI)

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etiology (ET)

genetics (GE)

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immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

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urine (UR)

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virology (VI)

Concept UI: M0018971
Scope Note: Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
Terms: Retrograde Degeneration Preferred Term
Term UI T036253
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Axonal Reaction
Term UI T036255
Date12/03/1990
LexicalTag NON
ThesaurusID NLM (1992); Nissl Degeneration
Term UI T036252
Date07/09/1996
LexicalTag EPO
ThesaurusID NLM (1998); Axon Reaction
Term UI T036254
Date12/03/1990
LexicalTag NON
ThesaurusID NLM (1992)

Retrograde Degeneration MeSH Descriptor Data 2023