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Rifampin MeSH Descriptor Data 2021


MeSH Heading
Rifampin
Tree Number(s)
D03.633.400.811.700
D04.345.295.750.700
Unique ID
D012293
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D012293
Scope Note
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Entry Term(s)
Benemycin
Rifadin
Rifampicin
Rimactan
Rimactane
Tubocin
Pharm Action
Antibiotics, Antitubercular
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers
Registry Number
VJT6J7R4TR
Related Numbers
13292-46-1
CAS Type 1 Name
Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-
NLM Classification #
QV 268
Previous Indexing
Rifamycins (1966-1972)
Public MeSH Note
73
History Note
73
Date Established
1973/01/01
Date of Entry
1999/01/01
Revision Date
2016/05/31
Rifampin Preferred
Rimactan Narrower
Tubocin Narrower
Rifadin Narrower
Rimactane Narrower
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