MeSH Browser

MeSH Heading: Rifampin
Tree Number(s): D03.633.400.811.700; D04.345.295.750.700
Unique ID: D012293
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012293
Scope Note: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Entry Term(s): Benemycin; Rifadin; Rifampicin; Rimactan; Rimactane; Tubocin
Pharm Action: Antibiotics, Antitubercular
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers
Related Numbers: 13292-46-1
CAS Type 1 Name: Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-
NLM Classification #: QV 268
Previous Indexing: Rifamycins (1966-1972)
Public MeSH Note: 73
History Note: 73
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0019110
Related Numbers: 13292-46-1
Scope Note: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Terms: Rifampin Preferred Term
Term UI T036501
Date01/01/1999
LexicalTag NON
ThesaurusID; Benemycin
Term UI T036499
Date07/13/1981
LexicalTag NON
ThesaurusID UNK (19XX); Rifampicin
Term UI T036500
Date03/30/1974
LexicalTag NON
ThesaurusID

Rifampin MeSH Descriptor Data 2025