MeSH Browser

MeSH Heading: Saralasin
Tree Number(s): D12.644.456.073.041.800; D23.469.050.050.050.700
Unique ID: D012504
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012504
Scope Note: An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.
Entry Term(s): (Sar(1),Ala(8))ANGII; (Sar1,Val5,Ala8)Angiotensin II; 1-Sar-8-Ala Angiotensin II; 1-Sarcosine-8-Alanine Angiotensin II; Angiotensin II, Sar(1)-Ala(8)-; Angiotensin II, Sarcosyl(1)-Alanine(8)-; Sar-Arg-Val-Tyr-Val-His-Pro-Ala; Saralasin Acetate; Saralasin Acetate, Anhydrous; Saralasin Acetate, Hydrated
Pharm Action: Angiotensin II Type 1 Receptor Blockers
Registry Number: H2AFV2HE66
Related Numbers: 34273-10-4; 39698-78-7; FO21Z580M4; U603K01682
CAS Type 1 Name: Angiotensin II, 1-(N-methylglycine)-5-L-valine-8-L-alanine-
NLM Classification #: QU 68
Previous Indexing: Alanine (1974); Angiotensin II (1974); Sarcosine (1974)
Public MeSH Note: 1984; see ANGIOTENSIN II 1978-83; 1-SARCOSINE-8-ALANINE ANGIOTENSIN II was indexed under ANGIOTENSIN II 1975-77
History Note: 1984(1978)
Date Established: 1984/01/01
Date of Entry: 1974/11/19
Revision Date: 2014/06/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0019423
Registry Number: H2AFV2HE66
Related Numbers: 34273-10-4; 39698-78-7; FO21Z580M4; U603K01682
Scope Note: An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.
Terms: Saralasin Preferred Term
Term UI T037104
Date01/01/1999
LexicalTag NON
ThesaurusID; (Sar1,Val5,Ala8)Angiotensin II
Term UI T037105
Date01/16/1991
LexicalTag NON
ThesaurusID NLM (1992); Sar-Arg-Val-Tyr-Val-His-Pro-Ala
Term UI T037107
Date08/31/1994
LexicalTag NON
ThesaurusID NLM (1996); 1-Sarcosine-8-Alanine Angiotensin II
Term UI T037103
Date04/28/1977
LexicalTag NON
ThesaurusID UNK (19XX); Angiotensin II, Sar(1)-Ala(8)-
Term UI T853137
Date01/08/2014
LexicalTag NON
ThesaurusID NLM (2015); Angiotensin II, Sarcosyl(1)-Alanine(8)-
Term UI T853138
Date01/08/2014
LexicalTag NON
ThesaurusID NLM (2015); (Sar(1),Ala(8))ANGII
Term UI T328321
LexicalTag NON
ThesaurusID NLM (2003); 1-Sar-8-Ala Angiotensin II
Term UI T037106
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Saralasin MeSH Descriptor Data 2023