MeSH Browser

MeSH Heading: Serotonin Antagonists
Tree Number(s): D27.505.519.625.850.850; D27.505.696.577.850.850
Unique ID: D012702
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012702
Annotation: general or unspecified; prefer specifics; differentiate from SEROTONIN UPTAKE INHIBITORS: do not confuse with SEROTONIN AGONISTS
Scope Note: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Entry Version: SEROTONIN ANTAG
Entry Term(s): 5-HT Antagonist; 5-HT Antagonists; 5-Hydroxytryptamine Antagonist; 5-Hydroxytryptamine Antagonists; Antagonists, 5-HT; Antagonists, 5-Hydroxytryptamine; Antagonists, Serotonin; Antiserotonergic Agent; Antiserotonergic Agents; Serotonin Antagonist; Serotonin Blockader; Serotonin Blockaders; Serotonin Receptor Antagonist; Serotonin Receptor Antagonists; Serotonin Receptor Blocker; Serotonin Receptor Blockers
NLM Classification #: QV 126
Previous Indexing: Serotonin (1966-1967); Serotonin/antagonists & inhibitors (1968-1977)
See Also: Selective Serotonin Reuptake Inhibitors
Public MeSH Note: 1978, 1964-1967
History Note: 1978(1964)
Date Established: 1978/01/01
Date of Entry: 1977/04/22
Revision Date: 2022/07/18

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Neurotransmitter Agents [D27.505.519.625]
      - Serotonin Agents [D27.505.519.625.850]
        
        Serotonin Receptor Agonists [D27.505.519.625.850.800]
        
        Serotonin Antagonists [D27.505.519.625.850.850]
        
        Serotonin 5-HT1 Receptor Antagonists [D27.505.519.625.850.850.100]
        
        Serotonin 5-HT2 Receptor Antagonists [D27.505.519.625.850.850.200]
        
        Serotonin 5-HT3 Receptor Antagonists [D27.505.519.625.850.850.300]
        
        Serotonin 5-HT4 Receptor Antagonists [D27.505.519.625.850.850.400]
        
        Selective Serotonin Reuptake Inhibitors [D27.505.519.625.850.900]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Neurotransmitter Agents [D27.505.696.577]
      - Serotonin Agents [D27.505.696.577.850]
        
        Serotonin Receptor Agonists [D27.505.696.577.850.800]
        
        Serotonin Antagonists [D27.505.696.577.850.850]
        
        Serotonin 5-HT1 Receptor Antagonists [D27.505.696.577.850.850.100]
        
        Serotonin 5-HT2 Receptor Antagonists [D27.505.696.577.850.850.200]
        
        Serotonin 5-HT3 Receptor Antagonists [D27.505.696.577.850.850.300]
        
        Serotonin 5-HT4 Receptor Antagonists [D27.505.696.577.850.850.400]
        
        Selective Serotonin Reuptake Inhibitors [D27.505.696.577.850.900]

Serotonin Antagonists Preferred

Concept UI: M0019685
Scope Note: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Terms: Serotonin Antagonists Preferred Term
Term UI T037559
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Antagonists, 5-Hydroxytryptamine
Term UI T037563
Date04/20/1992
LexicalTag NON
ThesaurusID NLM (1993); 5-Hydroxytryptamine Antagonists
Term UI T037564
Date04/14/1992
LexicalTag NON
ThesaurusID NLM (1993); Serotonin Receptor Antagonists
Term UI T829630
Date09/14/2012
LexicalTag NON
ThesaurusID NLM (2014); Serotonin Receptor Blockers
Term UI T829631
Date09/14/2012
LexicalTag NON
ThesaurusID NLM (2014); Serotonin Antagonist
Term UI T000997916
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); 5-HT Antagonist
Term UI T000997917
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); 5-Hydroxytryptamine Antagonist
Term UI T000997918
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Antiserotonergic Agent
Term UI T000997919
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Serotonin Blockader
Term UI T000997921
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Serotonin Receptor Antagonist
Term UI T000997922
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Serotonin Receptor Blocker
Term UI T000997923
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Antiserotonergic Agents
Term UI T037557
Date04/20/1977
LexicalTag NON
ThesaurusID UNK (19XX); Antagonists, Serotonin
Term UI T037558
Date04/20/1992
LexicalTag NON
ThesaurusID NLM (1993); Serotonin Blockaders
Term UI T037560
Date04/20/1977
LexicalTag NON
ThesaurusID UNK (19XX); 5-HT Antagonists
Term UI T037562
Date04/14/1992
LexicalTag NON
ThesaurusID NLM (1993); Antagonists, 5-HT
Term UI T037561
Date04/20/1992
LexicalTag NON
ThesaurusID NLM (1993)

Serotonin Antagonists MeSH Descriptor Data 2025