MeSH Browser

MeSH Heading: Sphingomyelin Phosphodiesterase
Tree Number(s): D08.811.277.352.640.750
Unique ID: D013108
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013108
Annotation: /defic: consider also NIEMANN-PICK DISEASE
Scope Note: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
Entry Term(s): Sphingomyelin Cholinephosphohydrolase; Sphingomyelin Cleaving Enzyme; Sphingomyelinase; Sphingomyelinase C
CAS Type 1 Name: Sphingomyelin cholinephosphohydrolase
Previous Indexing: Phosphodiesterases (1973-1974); Sphingomyelins (1973-1974)
See Also: Niemann-Pick Diseases
Public MeSH Note: 91; was see under PHOSPHODIESTERASES 1975-90
History Note: 91(75); was see under PHOSPHODIESTERASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0020300
Scope Note: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
Terms: Sphingomyelin Phosphodiesterase Preferred Term
Term UI T038575
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Sphingomyelin Cholinephosphohydrolase
Term UI T038573
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Sphingomyelin Cleaving Enzyme
Term UI T038574
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Sphingomyelinase
Term UI T038576
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Sphingomyelinase C
Term UI T038577
Date06/29/1983
LexicalTag NON
ThesaurusID UNK (19XX)

Sphingomyelin Phosphodiesterase MeSH Descriptor Data 2025