Succinate Dehydrogenase MeSH Descriptor Data 2025

MeSH Heading: Succinate Dehydrogenase
Tree Number(s): D05.500.562.750.249.500; D08.811.600.250.500.750.500; D08.811.600.250.875.249.500; D08.811.682.660.385.500; D08.811.682.830.249.500; D12.776.157.427.374.375.909.500; D12.776.331.199.750.500; D12.776.543.277.500.750.500; D12.776.543.277.875.249.500; D12.776.556.579.374.375.141.500
Unique ID: D013385
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013385
Scope Note: A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
Entry Term(s): Fumarate Reductase; Succinic Dehydrogenase; Succinic Oxidase
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Multienzyme Complexes [D05.500.562]
    - Succinate Cytochrome c Oxidoreductase [D05.500.562.750]
      - Electron Transport Complex II [D05.500.562.750.249]
        
        Succinate Dehydrogenase [D05.500.562.750.249.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multienzyme Complexes [D08.811.600]
    - Electron Transport Chain Complex Proteins [D08.811.600.250]
      - Electron-Transferring Flavoproteins [D08.811.600.250.500]
        
        Electron Transport Complex II [D08.811.600.250.500.750]
        
        Succinate Dehydrogenase [D08.811.600.250.500.750.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multienzyme Complexes [D08.811.600]
    - Electron Transport Chain Complex Proteins [D08.811.600.250]
      - Succinate Cytochrome c Oxidoreductase [D08.811.600.250.875]
        
        Electron Transport Complex II [D08.811.600.250.875.249]
        
        Succinate Dehydrogenase [D08.811.600.250.875.249.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxidoreductases Acting on CH-CH Group Donors [D08.811.682.660]
      - Electron Transport Complex II [D08.811.682.660.385]
        
        Succinate Dehydrogenase [D08.811.682.660.385.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Succinate Cytochrome c Oxidoreductase [D08.811.682.830]
      - Electron Transport Complex II [D08.811.682.830.249]
        
        Succinate Dehydrogenase [D08.811.682.830.249.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Iron-Binding Proteins [D12.776.157.427]
      - Nonheme Iron Proteins [D12.776.157.427.374]
        
        Iron-Sulfur Proteins [D12.776.157.427.374.375]
        
        Electron Transport Complex II [D12.776.157.427.374.375.909]
        
        Succinate Dehydrogenase [D12.776.157.427.374.375.909.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Flavoproteins [D12.776.331]
    - Electron-Transferring Flavoproteins [D12.776.331.199]
      - Electron Transport Complex II [D12.776.331.199.750]
        
        Succinate Dehydrogenase [D12.776.331.199.750.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Electron Transport Chain Complex Proteins [D12.776.543.277]
      - Electron-Transferring Flavoproteins [D12.776.543.277.500]
        
        Electron Transport Complex II [D12.776.543.277.500.750]
        
        Succinate Dehydrogenase [D12.776.543.277.500.750.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Electron Transport Chain Complex Proteins [D12.776.543.277]
      - Succinate Cytochrome c Oxidoreductase [D12.776.543.277.875]
        
        Electron Transport Complex II [D12.776.543.277.875.249]
        
        Succinate Dehydrogenase [D12.776.543.277.875.249.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Metalloproteins [D12.776.556]
    - Iron-Binding Proteins [D12.776.556.579]
      - Nonheme Iron Proteins [D12.776.556.579.374]
        
        Iron-Sulfur Proteins [D12.776.556.579.374.375]
        
        Electron Transport Complex II [D12.776.556.579.374.375.141]
        
        Succinate Dehydrogenase [D12.776.556.579.374.375.141.500]

Succinate Dehydrogenase Preferred

Concept UI: M0020703
Scope Note: A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
Terms: Succinate Dehydrogenase Preferred Term
Term UI T039275
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Fumarate Reductase
Term UI T039274
Date11/20/1980
LexicalTag NON
ThesaurusID UNK (19XX); Succinic Dehydrogenase
Term UI T039276
Date10/23/1981
LexicalTag NON
ThesaurusID UNK (19XX); Succinic Oxidase
Term UI T039277
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX)

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