MeSH Browser

MeSH Heading: Threonine Dehydratase
Tree Number(s): D08.811.520.232.400.850
Unique ID: D013913
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013913
Scope Note: A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.
Entry Term(s): Threonine Ammonia-Lyase; Threonine Deaminase; Threonine Dehydrase
Registry Numbers: EC 4.3.1.19
Related Numbers: 9024-34-4
CAS Type 1 Name: L-Threonine hydro-lyase (deaminating)
Previous Indexing: Hydro-Lyases (1966-1974); Threonine (1966-1974)
Public MeSH Note: 78; was see under HYDRO-LYASES 1975-77
History Note: 78(75); was see under HYDRO-LYASES 1975-77
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0021416
Registry Numbers: EC 4.3.1.19
Related Numbers: 9024-34-4
Scope Note: A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.
Terms: Threonine Dehydratase Preferred Term
Term UI T040799
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Threonine Ammonia-Lyase
Term UI T638317
Date04/28/2005
LexicalTag NON
ThesaurusID NLM (2006); Threonine Deaminase
Term UI T040798
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Threonine Dehydrase
Term UI T040800
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Threonine Dehydratase MeSH Descriptor Data 2024