MeSH Browser

MeSH Heading: Thyroxine
Tree Number(s): D06.472.931.812; D12.125.072.050.767
Unique ID: D013974
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013974
Annotation: /blood: consider also HYPERTHYROXINEMIA
Scope Note: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Entry Term(s): 3,5,3',5'-Tetraiodothyronine; Berlthyrox; Dexnon; Eferox; Eltroxin; Eltroxine; Euthyrox; Eutirox; L-3,5,3',5'-Tetraiodothyronine; L-Thyrox; L-Thyroxin Henning; L-Thyroxin beta; L-Thyroxine; L-Thyroxine Roche; Levo-T; Levothroid; Levothyroid; Levothyroxin Deladande; Levothyroxin Delalande; Levothyroxine; Levothyroxine Sodium; Levoxine; Levoxyl; Lévothyrox; Novothyral; Novothyrox; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; Oroxine; Sodium Levothyroxine; Synthroid; Synthrox; T4 Thyroid Hormone; Thevier; Thyrax; Thyroxin; Tiroidine; Tiroxina Leo; Unithroid
Related Numbers: 51-48-9; 7488-70-2
CAS Type 1 Name: Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
NLM Classification #: WK 202
See Also: Hyperthyroxinemia; Receptors, Thyroid Hormone
Public MeSH Note: 1965; see THYROXIN 1963-1964; for LEVOTHYROXINE see LEVOTHYROXINE 1991-2001, see THYROXINE 1966-1990, see LEVOTHYROXINE 1963-1965
History Note: 1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/02/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Thyroid Hormones [D06.472.931]

Amino Acids, Peptides, and Proteins [D12]
- Amino Acids [D12.125]
  - Amino Acids, Cyclic [D12.125.072]
    - Amino Acids, Aromatic [D12.125.072.050]

Thyroxine Preferred

Concept UI: M0021504
Related Numbers: 51-48-9; 7488-70-2
Scope Note: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Terms: Thyroxine Preferred Term
Term UI T040985
Date01/01/1999
LexicalTag NON
ThesaurusID; 3,5,3',5'-Tetraiodothyronine
Term UI T040984
Date07/31/1980
LexicalTag NON
ThesaurusID UNK (19XX); T4 Thyroid Hormone
Term UI T040986
Date05/19/1981
LexicalTag NON
ThesaurusID UNK (19XX); Thyroxin
Term UI T040987
Date03/27/1987
LexicalTag NON
ThesaurusID UNK (19XX); O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
Term UI T040988
Date03/16/1995
LexicalTag NON
ThesaurusID NLM (1996)

Eltroxine Narrower

Novothyral Narrower

Levothyroid Narrower

Levothyroxine Sodium Narrower

Levoxine Narrower

Synthroid Narrower

Levoxyl Narrower

Berlthyrox Narrower

Dexnon Narrower

Eferox Narrower

Eltroxin Narrower

Euthyrox Narrower

L-Thyroxin beta Narrower

L-Thyroxin Henning Narrower

L-Thyroxine Roche Narrower

L-Thyrox Narrower

Levo-T Narrower

Levothroid Narrower

Levothyroxin Deladande Narrower

Thyrax Narrower

Lévothyrox Narrower

Novothyrox Narrower

Oroxine Narrower

Synthrox Narrower

Tiroidine Narrower

Tiroxina Leo Narrower

Unithroid Narrower

Levothyroxine Narrower

Concept UI: M000640387
Terms: Levothyroxine Preferred Term
Term UI T048346
Date01/01/1999
LexicalTag NON
ThesaurusID; L-3,5,3',5'-Tetraiodothyronine
Term UI T048345
Date03/19/1990
LexicalTag NON
ThesaurusID NLM (1991); L-Thyroxine
Term UI T048348
Date03/19/1990
LexicalTag NON
ThesaurusID; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine
Term UI T048349
Date03/16/1995
LexicalTag NON
ThesaurusID NLM (1996)

Thyroxine MeSH Descriptor Data 2025