MeSH Browser

MeSH Heading: Apolipoprotein A-I
Tree Number(s): D10.532.091.200.100; D12.776.070.400.200.100; D12.776.521.120.200.100
Unique ID: D016632
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016632
Scope Note: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Entry Term(s): Apo A-1; Apo A-I; Apo A-I Isoproteins; Apo A1; Apo AI; ApoA-1; ApoA-I; Apolipoprotein A-1; Apolipoprotein A-I Isoprotein-2; Apolipoprotein A-I Isoprotein-4; Apolipoprotein A-I Isoproteins; Apolipoprotein A1; Apolipoprotein AI; Apolipoprotein AI Propeptide; Pro-Apo A-I; Pro-Apolipoprotein A-I; Proapolipoprotein AI
Previous Indexing: Apolipoproteins (1977-1984); Apolipoproteins A (1985-1991)
Public MeSH Note: 1992; APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A 1985-1991, under APOLIPOPROTEINS 1979-1984 & under APOPROTEINS 1974-1978; PRO-APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; APOLIPOPROTEIN A-I ISOPROTEINS was indexed under APOLIPOPROTEINS A 1980-2006
History Note: 1992 (1974); for PRO-APOLIPOPROTEIN A-I (NM) use APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; for APOLIPOPROTEIN A-I ISOPROTEINS (NM) use APOLIPOPROTEINS A 1980-2006
Date Established: 1992/01/01
Date of Entry: 1991/01/24
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Lipids [D10]
- Lipoproteins [D10.532]
  - Apolipoproteins [D10.532.091]
    - Apolipoproteins A [D10.532.091.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Apoproteins [D12.776.070]
    - Apolipoproteins [D12.776.070.400]
      - Apolipoproteins A [D12.776.070.400.200]
        
        Apolipoprotein A-I [D12.776.070.400.200.100]
        
        Apolipoprotein A-II [D12.776.070.400.200.150]
        
        Apolipoprotein A-V [D12.776.070.400.200.575]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Lipoproteins [D12.776.521]
    - Apolipoproteins [D12.776.521.120]
      - Apolipoproteins A [D12.776.521.120.200]
        
        Apolipoprotein A-I [D12.776.521.120.200.100]
        
        Apolipoprotein A-II [D12.776.521.120.200.150]
        
        Apolipoprotein A-V [D12.776.521.120.200.575]

Apolipoprotein A-I Preferred

Concept UI: M0025348
Scope Note: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Terms: Apolipoprotein A-I Preferred Term
Term UI T049785
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1992); Apo A-I
Term UI T049784
Date10/31/1990
LexicalTag ABB
ThesaurusID NLM (1992); Apo A1
Term UI T049789
Date12/24/1990
LexicalTag ABB
ThesaurusID NLM (1992); Apo AI
Term UI T049791
Date11/28/1990
LexicalTag ABB
ThesaurusID NLM (1992); ApoA-1
Term UI T049788
Date12/24/1990
LexicalTag ABB
ThesaurusID NLM (1992); ApoA-I
Term UI T049793
Date10/31/1990
LexicalTag ABB
ThesaurusID NLM (1992); Apolipoprotein A-1
Term UI T049787
Date12/24/1990
LexicalTag NON
ThesaurusID NLM (1992); Apolipoprotein A1
Term UI T049790
Date12/24/1990
LexicalTag NON
ThesaurusID NLM (1992); Apo A-1
Term UI T049786
Date12/24/1990
LexicalTag ABB
ThesaurusID NLM (1992); Apolipoprotein AI
Term UI T049792
Date10/31/1990
LexicalTag NON
ThesaurusID NLM (1992)

Apolipoprotein A-I Isoprotein-2 Narrower

Apolipoprotein A-I Isoprotein-4 Narrower

Apolipoprotein A-I Isoproteins Narrower

Pro-Apolipoprotein A-I Narrower

Concept UI: M0117573
Terms: Pro-Apolipoprotein A-I Preferred Term
Term UI T147577
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apolipoprotein AI Propeptide
Term UI T147574
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Pro-Apo A-I
Term UI T147575
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Proapolipoprotein AI
Term UI T147576
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

Apolipoprotein A-I MeSH Descriptor Data 2025