MeSH Browser

MeSH Heading: ISCOMs
Tree Number(s): D20.215.894.860.449
Unique ID: D016882
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016882
Annotation: coord IM with specific type of vaccine (IM or NIM)
Scope Note: A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.
Entry Term(s): ISCOM; Immuno-Stimulating Complexes; Immunostimulating Complexes
Pharm Action: Adjuvants, Immunologic
Previous Indexing: Adjuvants, Immunologic (1985-1991); Viral Vaccines (1985-1991)
See Also: Saponins
Public MeSH Note: 92
History Note: 92
Date Established: 1992/01/01
Date of Entry: 1991/08/17
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0025686
Scope Note: A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.
Terms: ISCOMs Preferred Term
Term UI T050536
Date01/01/1999
LexicalTag ACR
ThesaurusID NLM (1992); Immuno-Stimulating Complexes
Term UI T050537
Date03/06/1991
LexicalTag NON
ThesaurusID NLM (1992); Immunostimulating Complexes
Term UI T050534
Date03/06/1991
LexicalTag NON
ThesaurusID NLM (1992); ISCOM
Term UI T050535
Date03/06/1991
LexicalTag ABB
ThesaurusID NLM (1992)

ISCOMs MeSH Descriptor Data 2025