MeSH Browser

MeSH Heading: Ribonucleoprotein, U4-U6 Small Nuclear
Tree Number(s): D12.776.157.725.500.875.615; D12.776.664.962.500.875.615
Unique ID: D017414
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017414
Scope Note: A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.
Entry Term(s): Ribonucleoproteins, Small, U4-U6; Ribonucleoproteins, U4 Small Nuclear; Ribonucleoproteins, U6 Small Nuclear; Small Nuclear Ribonucleoproteins, U4; Small Nuclear Ribonucleoproteins, U4-U6; Small Nuclear Ribonucleoproteins, U6; U4 Small Nuclear Ribonucleoproteins; U4 snRNP; U4-U6 Small Nuclear Ribonucleoproteins; U4-U6 snRNP; U6 Small Nuclear Ribonucleoproteins; U6 snRNP
Previous Indexing: Ribonucleoproteins (1982-1992)
Public MeSH Note: 2000; RIBONUCLEOPROTEINS, SMALL, U4-U6 was heading 1993-1999; U4 RNP & U6 RNP were indexed under RIBONUCLEPROTEINS 1982-92
History Note: 2000; U4 SNRNP was U4 RNP (SY) to SMALL NUCLEAR RIBONUCLEOPROTEINS (NM) 1982-92; U6 SNRNP was U6 RNP (SY) to SMALL NUCLEAR RIBONUCLEOPROTEINS (NM) 1982-92
Date Established: 1993/01/01
Date of Entry: 1992/05/22
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0026433
Scope Note: A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.
Terms: Ribonucleoprotein, U4-U6 Small Nuclear Preferred Term
Term UI T365026
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); U4-U6 snRNP
Term UI T052093
Date03/25/1992
LexicalTag ABB
ThesaurusID NLM (1993); Ribonucleoproteins, Small, U4-U6
Term UI T052094
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1993); Small Nuclear Ribonucleoproteins, U4-U6
Term UI T052095
Date03/25/1992
LexicalTag NON
ThesaurusID NLM (1993); U4-U6 Small Nuclear Ribonucleoproteins
Term UI T052096
Date03/25/1992
LexicalTag NON
ThesaurusID NLM (1993)

Ribonucleoprotein, U4-U6 Small Nuclear MeSH Descriptor Data 2025