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A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
Entry Version
RECEPT SIGMA
Entry Term(s)
Opioid Receptors, sigma
Receptors, Opioid, sigma
Receptors, sigma Opioid
sigma Receptor
sigma Receptors
Registry Numbers
0
Previous Indexing
Receptors, Endorphin (1981-1992)
Public MeSH Note
93; SIGMA RECEPTOR was indexed under RECEPTORS, ENDORPHIN 1981-92
Online Note
use RECEPTORS, SIGMA (NM) to search SIGMA RECEPTOR 1981-92
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.