MeSH Browser

MeSH Heading: Receptors, sigma
Tree Number(s): D12.776.543.750.695.620.775; D12.776.543.750.720.600.610.775; D12.776.543.750.750.555.610.775
Unique ID: D017480
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017480
Scope Note: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
Entry Version: RECEPT SIGMA
Entry Term(s): Opioid Receptors, sigma; Receptors, Opioid, sigma; Receptors, sigma Opioid; sigma Receptor; sigma Receptors
Registry Numbers: 0
Previous Indexing: Receptors, Endorphin (1981-1992)
Public MeSH Note: 93; SIGMA RECEPTOR was indexed under RECEPTORS, ENDORPHIN 1981-92
Online Note: use RECEPTORS, SIGMA (NM) to search SIGMA RECEPTOR 1981-92
History Note: 93; was SIGMA RECEPTOR (NM) 1981-92
Date Established: 1993/01/01
Date of Entry: 1992/05/22
Revision Date: 2016/06/17

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0026516
Registry Numbers: 0
Scope Note: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
Terms: Receptors, sigma Preferred Term
Term UI T052434
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1993); Receptors, sigma Opioid
Term UI T052437
Date04/17/1992
LexicalTag NON
ThesaurusID NLM (1993); sigma Receptor
Term UI T052432
Date03/04/1993
LexicalTag NON
ThesaurusID NLM (1994); sigma Receptors
Term UI T052433
Date04/01/1992
LexicalTag NON
ThesaurusID NLM (1993); Opioid Receptors, sigma
Term UI T052435
Date04/17/1992
LexicalTag NON
ThesaurusID NLM (1993); Receptors, Opioid, sigma
Term UI T052436
Date09/25/1995
LexicalTag NON
ThesaurusID NLM (1997)

Receptors, sigma MeSH Descriptor Data 2025