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Leukotriene A4 MeSH Descriptor Data 2023


MeSH Heading
Leukotriene A4
Tree Number(s)
D10.251.355.255.100.450.405
D10.251.355.310.166.887.405
D23.469.050.175.450.400
Unique ID
D017572
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017572
Annotation
/biosyn /‌physiol permitted
Scope Note
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Entry Term(s)
LTA4
Leukotriene A
Leukotriene A-4
Leukotrienes A
Registry Number
0
Previous Indexing
Arachidonic Acids (1980-1988)
Leukotrienes (1989-1993)
Public MeSH Note
94; LEUKOTRIENE A was indexed under LEUKOTRIENES 1989-93 & ARACHIDONIC ACIDS 1980-88
Online Note
use LEUKOTRIENE A4 (NM) to search LEUKOTRIENE A 1980-93
History Note
94; was LEUKOTRIENE A (NM) 1980-93
Date Established
1994/01/01
Date of Entry
1993/06/04
Revision Date
2015/06/08
Leukotriene A4 Preferred
Leukotriene A Broader
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