MeSH Browser

MeSH Heading: Leukotriene A4
Tree Number(s): D10.251.355.255.100.450.405; D10.251.355.310.166.887.405; D23.469.050.175.450.400
Unique ID: D017572
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017572
Annotation: /biosyn /‌physiol permitted
Scope Note: (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Entry Term(s): LTA4; Leukotriene A; Leukotriene A-4; Leukotrienes A
Registry Number: 0
Previous Indexing: Arachidonic Acids (1980-1988); Leukotrienes (1989-1993)
Public MeSH Note: 94; LEUKOTRIENE A was indexed under LEUKOTRIENES 1989-93 & ARACHIDONIC ACIDS 1980-88
Online Note: use LEUKOTRIENE A4 (NM) to search LEUKOTRIENE A 1980-93
History Note: 94; was LEUKOTRIENE A (NM) 1980-93
Date Established: 1994/01/01
Date of Entry: 1993/06/04
Revision Date: 2015/06/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0026633
Registry Number: 0
Scope Note: (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Terms: Leukotriene A4 Preferred Term
Term UI T052688
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1994); Leukotriene A-4
Term UI T052690
Date05/10/1993
LexicalTag NON
ThesaurusID NLM (1994); LTA4
Term UI T052689
Date06/09/1992
LexicalTag ABB
ThesaurusID NLM (1993)

Leukotriene A4 MeSH Descriptor Data 2023