MeSH Browser

MeSH Heading: Immunoglobulin Class Switching
Tree Number(s): G05.344.401.501.450; G12.500.274.501.450
Unique ID: D017578
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017578
Scope Note: Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
Entry Version: IG CLASS SWITCHING
Entry Term(s): Class Switching; Ig Class Switching; Isotype Switching
Previous Indexing: Immunoglobulin Isotypes/biosynthesis (1988-1993); Immunoglobulins, Heavy-Chain/genetics (1980-1993)
Public MeSH Note: 94
History Note: 94
Date Established: 1994/01/01
Date of Entry: 1993/06/17
Revision Date: 2019/07/05

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0026640
Scope Note: Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
Terms: Immunoglobulin Class Switching Preferred Term
Term UI T052708
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1994); Ig Class Switching
Term UI T000952297
Date03/01/2019
LexicalTag NON
ThesaurusID NLM (2020); Class Switching
Term UI T052706
Date06/12/1992
LexicalTag NON
ThesaurusID NLM (1994); Isotype Switching
Term UI T052707
Date06/12/1992
LexicalTag NON
ThesaurusID NLM (1994)

Immunoglobulin Class Switching MeSH Descriptor Data 2025